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Global outbreak means that we see both spread of the agent …

and then we see disease activities in addition to the spread of the virus." In planning for a possible influenza pandemic, the WHO published a document on pandemic preparedness guidance in 1999, revised in 2005 and in February 2009, defining phases and appropriate actions for each phase in an aide memoir entitled WHO pandemic phase descriptions and main actions by phase.

Effective education about safer sexual practices and bloodborne infection precautions training have helped to slow down infection rates in several African countries sponsoring national education programs.

Infection rates are rising again in Asia and the Americas.

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Introduced diseases, notably smallpox, nearly wiped out the native population of Easter Island.In 1542, 30,000 soldiers died of typhus while fighting the Ottomans in the Balkans.During the Thirty Years' War (1618–1648), about 8 million Germans were killed by bubonic plague and typhus.This starts with the virus mostly infecting animals, with a few cases where animals infect people, then moves through the stage where the virus begins to spread directly between people, and ends with a pandemic when infections from the new virus have spread worldwide and it will be out of control until we stop it.A disease or condition is not a pandemic merely because it is widespread or kills many people; it must also be infectious.